Aspergillus and Aspergillosis - Part I

What is Aspergillus?
Aspergillus is a fungus (or mold) that is very common in the environment. It is found in soil, on plants and in decaying plant matter. It is also found in household dust, building materials, and even in spices and some food items. There are lots of different types of Aspergillus, but the most common ones are Aspergillus fumigatus and Aspergillus flavus. Some others are Aspergillus terreus, Aspergillus nidulans, and Aspergillus niger.

What is aspergillosis?
Aspergillosis is disease cause by Aspergillus. There are many different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis, a disease that usually affects people with immune system problems. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body.

Who gets aspergillosis?
ABPA can affect people who are otherwise healthy, but it is most common in people with asthma or cystic fibrosis. Invasive aspergillosis generally affects people who have compromised immune systems, such as people who have had a bone marrow transplant or solid organ transplant, people who are taking high doses of corticosteroids, and people getting chemotherapy for cancers such as leukemia. Rarely, persons with advanced HIV infection can acquire the infection.